A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1. The peptide is generated by the same proteolytic mechanism as Aβ42. Non-amyloidogenic APL1β28 can be detected in the CSF and its levels correlate with Aβ42 production. Its ratio to total APL1β (APL1β25, APL1β27, and APL1β28) is significantly increased in familial and sporadic cases of AD.

从β app样蛋白APLP1衍生的Aβ 1-42生产的高度敏感的生物标志物。该肽的产生机制与Aβ42相同。在脑脊液中可以检测到非淀粉样性APL1β28，其水平与Aβ42的产生相关。它与总APL1β (APL1β25、APL1β27和APL1β28)的比值在家族性和散发性AD病例中显著增加。

编号: 110157

中文名称: APL1β28

英文名: APL1β28

英文同义词: APLP1-derived Aβ-like peptide (1-28)

CAS号: 1233876-42-0

单字母: H2N-DELAPAGTGVSREAVSGLLIMGAGGGSL-OH

三字母: H2N-Asp-Glu-Leu-Ala-Pro-Ala-Gly-Thr-Gly-Val-Ser-Arg-Glu-Ala-Val-Ser-Gly-Leu-Leu-Ile-Met-Gly-Ala-Gly-Gly-Gly-Ser-Leu-COOH

氨基酸个数: 28

分子式: C109H185N31O39S1

平均分子量: 2585.88

精确分子量: 2584.32

等电点(PI): 3.93

pH=7.0时的净电荷数: -2.02

平均亲水性: -0.14

疏水性值: 0.53

来源: 人工化学合成，仅限科学研究使用，不得用于人体。

储存条件: 负80℃至负20℃