This N-terminal tripeptide of IGF-I facilitated the in vitro release of acetylcholine with a several hundredfold higher potency (10⁻¹⁰ - 10⁻⁶ M) than intact IGF-I (4 · 10⁻⁸ M), whereas truncated IGF-I lacking the tripeptide GPE, did not show any significant effect. This raises the possibility that GPE may be the active site of IGF-I. - Although the precise mode of action of GPE is still unknown, another study suggests that local administration of GPE is neuroprotective after brain HI injury via glial cells. In addition, systemic administration of GPE showed a more widespread neuroprotective effect. Therefore, GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects.这种IGF-I的n端三肽促进乙酰胆碱的体外释放，药效(10¹¹⁰- 10￣M)比完整的IGF-I(4·10￣M)高数百倍，而缺失GPE三肽的截断型IGF-I并没有表现出明显的效果。这就提出了GPE可能是IGF-I的活性位点的可能性。-虽然GPE的确切作用模式尚不清楚，但另一项研究表明，局部给药通过胶质细胞对脑HI损伤具有神经保护作用。此外，全身给药GPE表现出更广泛的神经保护作用。因此，GPE可能是中枢和全身IGF-1抗凋亡作用的补充途径。

编号: 138222

中文名称: 三肽Gly-Pro-Glu

英文名: Gly-Pro-Glu

CAS号: 32302-76-4

单字母: H2N-GPE-OH

三字母: H2N-Gly-Pro-Glu-COOH

氨基酸个数: 3

分子式: C12H19N3O6

平均分子量: 301.3

精确分子量: 301.13

等电点(PI): 3.85

pH=7.0时的净电荷数: -1.02

平均亲水性: 3

疏水性值: -1.83

来源: 人工化学合成，仅限科学研究使用，不得用于人体。

纯度: 95%、98%

盐体系: 可选TFA、HAc、HCl或其它

生成周期: 2-3周

储存条件: 负80℃至负20℃