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Catalogue Number:C955990
Chemical Name:(3S,5S)-6-Cyano-3,5-dihydroxyhexanoic Acid 1,1-Dimethylethyl Ester
CAS Number:1105067-92-2
Molecular Formula:C₁₁H₁₉NO₄
Molecular Weight:229.27
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(3S,5S)-6-Cyano-3,5-dihydroxyhexanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of (3S,5S)-Atorvastatin Sodium Salt (A791735), which is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References:Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18. 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)
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