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Catalogue Number:C981895
Chemical Name:(4R,6S)-6-(Cyanomethyl)-2,2-dimethyl--1,3-dioxane-4-acetic Acid tert-Butyl Ester
Synonyms:(4R,6S)-6-(Cyanomethyl)-2,2-dimethyl--1,3-dioxane-4-acetic Acid-1,1-dimethylethyl Ester; (4R-trans)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
CAS Number:196085-84-4
Molecular Formula:C₁₄H₂₃NO₄
Molecular Weight:269.34
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(4R,6S)-6-(Cyanomethyl)-2,2-dimethyl--1,3-dioxane-4-acetic Acid tert-Butyl Ester is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References:Mann, E.E., et. al.: J. Liq. Chromatogr. R. T., 20, 2441 (1997); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)
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