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Catalogue Number:C982020
Chemical Name:(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
Synonyms:6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-Dimethylethyl Ester, (4R-cis)-; ((4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-[1,3]dioxan-4-yl)acetic Acid tert-Butyl Ester; (6R-Cyanomethyl-2,2-dimethyl-[1,3]dioxan-4R-yl)acetic Acid tert-Butyl Ester
CAS Number:125971-94-0
Molecular Formula:C₁₄H₂₃NO₄
Appearance:White to Off-White Solid
Melting Point:112 - 113o C
Molecular Weight:269.34
Storage:-20°C
Solubility:Chloroform (Sparingly), Ethyl Acetate (Slightly), DMSO (Slightly)
Category:Building Blocks; Chiral Molecules;
Applications:(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References:Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),
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