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Catalogue Number:C982245
Chemical Name:2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide
Synonyms:2-Cyano-α,α,α-trifluoro-p-acetotoluidide; Leflunomide EP Impurity H
Impurity:Leflunomide EP Impurity H
CAS Number:24522-30-3
Molecular Formula:C₁₀H₇F₃N₂O
Appearance:White to Off-White Solid
Melting Point:195-196°C
Molecular Weight:228.17
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Miscellaneous;
Applications:2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.
References:Nikolakopoulos, G., et al.: Bioorg. Med. Chem., 14, 2358 (2006); Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 19, 1344 (2009)
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