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CAS:66845-32-7|[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN') Diiodoplatinum

发布时间:2024-05-29 分享至:

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Catalogue Number:C984525
Chemical Name:[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN') Diiodoplatinum
Synonyms:(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN,κN']diiodoplatinum; (1R-trans)-1,2-Cyclohexanediamine Platinum Complex; (trans-1R,2R-1,2-Diaminocyclohexane)diiodoplatinum; (trans-R,R-1,2-Diaminocyclohexane)diiodoplatinum; (trans-R,R-Cyclohexane-1,2-diamine)diiodoplatinum; Diiodo(trans-l-1,2-cyclohexanediamine)platinum; NSC 290127; [SP-4-2-(1R-trans)]-(1,2-cyclohexanediamine-N,N')diiodoplatinum; USP Oxiplatin Related Compound F;
CAS Number:66845-32-7
Molecular Formula:C₆H₁₄I₂N₂Pt
Appearance:Pale Yellow to Light Yellow Solid
Melting Point:>300°C
Molecular Weight:563.08
Storage:-20°C
Solubility:DMSO (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-κN,κN')diiodoplatinum is a potential antitumor agent. Impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References:Kidani, Y. et al.: Biomed. Pharmacther., 43, 261 (1989); Noji, M. et al.: J. Med. Chem., 24, 508 (1981); Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),
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