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Catalogue Number:C984565
Chemical Name:trans-1,2-Cyclohexanedicarboxylic Acid
Synonyms:(1R,2R)-rel-1,2-Cyclohexanedicarboxylic Acid; (±)-trans-1,2-Cyclohexanedicarboxylic Acid; NSC 31593
CAS Number:2305-32-0
Molecular Formula:C₈H₁₂O₄
Appearance:White Solid
Melting Point:229-231ºC
Molecular Weight:172.18
Storage:4°C
Solubility:Acetone (Slightly), DMSO (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (a-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.
References:Dossetter, A.G., et al.: J. Med. Chem., 55, 6363 (2012); Shao, P.P., et al.: Bioorg. Med. Chem. Lett., 15, 1901 (2005)
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