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Catalogue Number:C987465
Chemical Name:[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N’) Dichloridoplatinum(II)
Synonyms:[SP-4-2-(1R-trans)]-Dichloro(1,2-cyclohexanediamine-N,N')platinum; (SP-4-2)-Dichloro[(1R,2R)-1,2-cyclohexanediamine-κN,κN']platinum; (1R-trans)-1,2-Cyclohexanediamine Platinum Complex; Dichloro((1R,2R)-trans-diaminocyclohexane)platinum(II); Dichloro((R,R)-1,2-diaminocyclohexane)platinum; Dichloro(1R,2R-1,2-diaminocyclohexane)platinum; Dichloro(1R,2R-cyclohexanediammine)platinum(II); Dichloro(trans-R,R-1,2-diaminocyclohexane)platinum; Dichloro(trans-l-1,2-cyclohexanediamine)platinum(II); Dichloro[(1R,2R)-1,2-cyclohexanediamine]platinum; Dichloro[(R,R)-1,2-cyclohexanediamine]platinum; Dichloro[trans-(-)-1,2-cyclohexanediamine]platinum(II); NSC 265460; [SP-4-2-[1R-(trans)]]-Dichloro(1,2-cyclohexanediamine-κN,κN')-platinum; cis-Dichlorobis((1R,2R)-cyclohexanediamine)platinum
CAS Number:61848-66-6
Molecular Formula:C₆H₁₄Cl₂N₂Pt
Appearance:Yellow Solid
Melting Point:>256°C (dec.)
Molecular Weight:380.18
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,NтАЩ) Dichloridoplatinum(II) is an impurity of Oxiplatin (O845075), third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References:Kidani, Y. et al.: Biomed. Pharmacther., 43, 261 (1989); Noji, M. et al.: J. Med. Chem., 24, 508 (1981); Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),
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