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Catalogue Number:C987730
Chemical Name:CYC-116
Synonyms:5-[2,5-Dihydro-2-[[4-(4-morpholinyl)phenyl]imino]-4-pyrimidinyl]-4-methyl-2-thiazolamine;
CAS Number:1059105-22-4
Molecular Formula:C₁₈H₂₀N₆OS
Appearance:Pale Yellow Solid
Melting Point:270-277°C (dec.)
Molecular Weight:368.46
Storage:4°C, Hygroscopic
Solubility:Aqueous Acid, DMSO (Sparingly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:An Aurora kinase inhibitor, used to treat patients with advanced solid tumors.
References:Carlson, H., et al.: Mol. Pharmacol., 57, 213 (2000), Hou, T., et al.: Curr. Pharm. Des., 10, 1011 (2004), Verdonk, M., et al.: J. Med. Chem., 48, 6504 (2005),
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