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Catalogue Number:C988198
Chemical Name:4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide
CAS Number:1289942-55-7
Molecular Formula:C₂₀H₁₈F₄N₄O₂
Appearance:White to Off-White Solid
Melting Point:>232°C (dec.)
Molecular Weight:422.38
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide is an impurity of Enzalutamide (M199800), an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex.
References:Scher, H. I., et al.: Lancet, 375, 1437 (2010); Bellmunt, J., et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C. J., et al.: J. Clin. Oncol., 29, 3651 (2011);
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