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Catalogue Number:C988400
Chemical Name:Cyclopamine
Synonyms:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol; 11-Deoxojervine; (3β,23β)-17,23-Epoxyveratraman-3-ol;
CAS Number:4449-51-8
Molecular Formula:C₂₇H₄₁NO₂
Appearance:White to Off-White Solid
Melting Point:>227°C (dec.)
Molecular Weight:411.62
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Chiral Molecules; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Cyclopamine antibacterial properties. Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched. Potent Hedgehog inhibitor.Solubility: 1mg of Cyclopamine dissolves in 0.2ml DMSO with heating to approximately 70 degrees (ca. 12 mmol sol.)Solubility: 4mg of Cyclopamine dissolves in 1ml 95% Ethanol
References:Kanda, S., et al.: J. Biol. Chem., 278,10, 8244 (2003), Rao, et al.: Development, 130, 1549 (2003), Taipale, J., et al. Nature 406, 1005 (2000), Perron, M., et al. Development 130, 1565 (2003), Watkins, D.N., et al.: Nature, 422, 313 (2003)
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