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Catalogue Number:D229145
Chemical Name:6-Dehydrocortisol
Synonyms:NSC 12881; Δ6-Cortisol; Δ6-Hydrocortisone; (11β)-11,17,21-Trihydroxy-Pregna-4,6-diene-3,20-dione; Hydrocortisone EP Impurity E
Impurity:Hydrocortisone EP Impurity E
CAS Number:600-99-7
Molecular Formula:C₂₁H₂₈O₅
Appearance:Pale Yellow Solid
Melting Point:227 - 235°C
Molecular Weight:360.44
Storage:4°C
Solubility:Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Standards; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:6-Dehydrocortisol (Hydrocortisone EP Impurity E) is a metabolite of Cortisol (H714615), a glucocorticoid, produced by the zona fasciculata of the adrenal gland. 6-Dehydrocortisol was used in the identification of Trp-371 as the main site of specific photoaffinity labeling of corticosteroid binding globulin.
References:Grenot, C., et al.: Biochem., 33, 8969 (1994); Justice, J.B., et al.: J. Med. Chem., 21, 465 (1978); Vigore, L., et al.: Cancer Ther., 6, 699 (2008),
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