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CAS:1074549-89-5|4,5-Dehydro Apixaban

发布时间:2024-05-31 分享至:

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Catalogue Number:D229385
Chemical Name:4,5-Dehydro Apixaban
Synonyms:1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6,7-Dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxamide
CAS Number:1074549-89-5
Molecular Formula:C₂₅H₂₃N₅O₄
Appearance:White to Pale Beige Solid
Melting Point:>252°C (dec.)
Molecular Weight:457.48
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation
References:Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)
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