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Catalogue Number:D230465
Chemical Name:1-Demethylcolchicine
Synonyms:1-Demethylcolchicine; Benzo[a]heptalene Acetamide Derivative; (-)-1-Demethylcolchicine; 1-Demethylcolchicine; Demethyl-colchicine
CAS Number:3464-68-4
Molecular Formula:C₂₁H₂₃NO₆
Molecular Weight:385.41
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-Demethylcolchicine is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References:Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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