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Catalogue Number:D230653
Chemical Name:Dehydroxy-(2-methyl-4-(2-methylbenzamido)benzoate) Tolvaptan
Synonyms:4-[(2-Methylbenzoyl)amino]-2-methylbenzoic Acid 1-[4-[(2-Methylbenzoyl)amino]-2-methylbenzoyl]-7-chloro-2,3-dihydro-1H-benzo[b]azepin-5-yl Ester;
CAS Number:1580889-36-6
Molecular Formula:C₄₂H₃₆ClN₃O₅
Molecular Weight:698.21
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Dehydroxy-(2-methyl-4-(2-methylbenzamido)benzoate) Tolvaptan is the impurity of the drug Tolvaptan (T536650), which is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References:Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);
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