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Catalogue Number:D230710
Chemical Name:Delanzomib
Synonyms:[(1R)-1-[[(2S,3R)-3-Hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]boronic Acid; CEP 18770; CIP 18770; CT 47098; NPH 007098; [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic Acid;
CAS Number:847499-27-8
Molecular Formula:C₂₁H₂₈BN₃O₅
Appearance:White to Off-White Solid
Melting Point:178-190°C (dec.)
Molecular Weight:413.28
Storage:-20°C
Solubility:Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.
References:Piva, R. et al.: Blood, 111, 2765 (2008); Sanchez, E. et al.: Br. J. Haematol., 148, 569 (2010);
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