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Catalogue Number:D230750
Chemical Name:Demecolceine
Synonyms:(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; 7-Deacetamido-7-(methylamino)colchiceine;
CAS Number:518-11-6
Molecular Formula:C₂₀H₂₃NO₅
Appearance:Pale Yellow to Yellow Solid
Melting Point:120-122°C
Molecular Weight:357.4
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly, Heated)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors;
Applications:An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References:Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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