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Catalogue Number:D231285
Chemical Name:7-O-Demethyl a-Narcotine
Synonyms:(3S)-7-Hydroxy-6-methoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone; [S-(R*,S*)]-7-hydroxy-6-methoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone; 7-Hydroxy-α-narcotine;
CAS Number:68353-55-9
Molecular Formula:C₂₁H₂₁NO₇
Appearance:White to Pale Yellow Solid
Melting Point:> 158°C (dec.)
Molecular Weight:399.39
Storage:-20°C
Solubility:Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites; Natural Products;
Applications:7-O-Demethyl a-Narcotine, is a derivative of Narcotine (N378890), a noscapinoid class of microtubule binding compounds that alter microtubule dynamics without affecting tubulin polymer mass. Noscapinoids show great promise as chemotherapeutic agents for the treatment of human cancers. Unlike Narcotine, (-)-a-Narcotinediol deos not inhibit small-intestinal transport in rats.
References:Naik, P. et al.: J. Mol. Mod., 18, 307 (2012); Marazova, K. et al.: Pharmazie., 43, 561 (1988)
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