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Catalogue Number:D231320
Chemical Name:N-Demethyl Lincomycin Hydrochloride
Synonyms:Methyl 6,8-Dideoxy-6-[[[(2S,4R)-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside Monohydrochloride; Methyl 6,8-Dideoxy-6-(4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-D-galacto-octopyranoside Hydrochloride; trans-α-Methyl 6,8-Dideoxy-6-(4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-D-galacto-octopyranoside; 4'-Propyl-N-demethyllincomycin
CAS Number:14600-41-0
Alternate CAS #
free base: 2256-16-8
Molecular Formula:C₁₇H₃₂N₂O₆S • HCl
Appearance:White to Off-White Solid
Melting Point:>162°C (dec.)
Molecular Weight:392.51 + 36.46
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Stability
Hygroscopic
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Carbohydrates and Oligosaccharides;
Applications:N-Demethyl Lincomycin Hydrochloride is an impurity of Lincomycin (L466200), an antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References:Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962); Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964); Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)
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