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Catalogue Number:D231330
Chemical Name:3-Demethyl Thiocolchicine
Synonyms:N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; 2-Demethylthio-colchicine; 3-Demethylthiocolchicine; 3-Desmethylthiocolchicine; 3-O-Demethylthiocolchicine; NSC 361792;
CAS Number:87424-25-7
Molecular Formula:C₂₁H₂₃NO₅S
Appearance:Light Yellow to Light Green Solid
Melting Point:>300°C
Molecular Weight:401.48
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Very Slightly, Heated)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:A Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Trellu, M., et al.: Fund. Clin. Pharmacol., 18, 493 (2004), Nakagawa-Goto, K., et al.: Bioorg. Med. Chem. Lett., 15, 235 (2005), Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2007),
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