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Catalogue Number:D231400
Chemical Name:Denbufylline
Synonyms:1,3-Di-n-butyl-7-[2’-oxopropyl)xanthine; BRL 30892; 1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione;
CAS Number:57076-71-8
Molecular Formula:C₁₆H₂₄N₄O₃
Appearance:White to Pale Beige Solid
Melting Point:98-100°C
Molecular Weight:320.39
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle apaillary muscle independently of its PDE inhibitory activity.
References:Nicholson, C.D., et al.: Br. J. Pharmacol., 97, 889 (1989), Cortijo, J., et al.: Br. J. Pharmacol., 108, 562 (1993), Sanae, F., et al.: J. Pharmacol. Exp. Ther., 277, 54 (1996), Kumari, M., et al.: Br. J. Pharmacol., 121, 459 (1997),
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