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Catalogue Number:D231408
Chemical Name:Demethylzeylasteral
Synonyms:(20α)-2,3-Dihydroxy-6,23-dioxo-D:A-friedo-24-noroleana-1,3,5(10),7-tetraen-29-oic Acid; (9β,13α,14β,20α)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic Acid; TZ 93;
CAS Number:107316-88-1
Molecular Formula:C₂₉H₃₆O₆
Appearance:Yellow Solid
Melting Point:>221°C (dec.)
Molecular Weight:480.59
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Monomers; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.
References:Xu, M., et al.: Anal. Chem., 88, 8050-8057 (2016); An, H., et al.: Cell Biochem. Biophys., 73, 673-679 (2015)
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