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Catalogue Number:D231425
Chemical Name:4-O-Demtheyl Aliskiren
Synonyms:(αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ,4-dihydroxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide; (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-(4-hydroxy-3-(3-methoxypropoxy)benzyl)-2-isopropyl-8-methylnonanamide
CAS Number:949925-74-0
Molecular Formula:C₂₉H₅₁N₃O₆
Molecular Weight:537.73
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-O-Demtheyl Aliskiren is a metabolite of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References:Waldmeier, F., et. al.: Drug Metab. Dispos., 35, 1418 (2007); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)
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