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Catalogue Number:D232545
Chemical Name:5'-Deoxy-5'-chloroadenosine
Synonyms:5'-Chloro-5'-deoxyadenosine;
CAS Number:892-48-8
Molecular Formula:C₁₀H₁₂ClN₅O₃
Appearance:Off-White to Light Beige Solid
Melting Point:>168°C (dec.)
Molecular Weight:285.69
Storage:-20°C
Solubility:DMSO (Slightly), Water (Slightly, Heated)
Category:Building Blocks; Carbohydrates and Oligosaccharides;
Applications:5'-Deoxy-5'-chloroadenosine is an intermediate in the synthesis of 5'-Deoxy-5'-(methylthio)adenosine (D242600), a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
References:Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),
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