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Catalogue Number:D232855
Chemical Name:rac-2-Deoxy-D-erythro-pentofuranose 3,5-Di-p-toluate(Decitabine Impurity)
Synonyms:p-Toluic Acid 3,5-Diester with 2-Deoxy-D-erythro-pentofuranose
CAS Number:17117-72-5
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.4
Category:Research Tools;
Applications:2-Deoxy-D-erythro-pentofuranose 3,5-di-p-toluate is an impurity of Decitabine (α-isomer: D226730), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, “normalizing” gene expression in cancerous cells.
References:Aribi, A., et al.: Cancer, 109, 713 (2007); Issa, J., et al.: Blood, 103, 1635 (2004); Kantarjian , H., et al.: Cancer, 98, 522 (2003); Momparler, R., et al.: Anti-Cancer Drug., 8, 358 (1997); Plimack, E., et al.: Leukemia Lymphoma, 48, 1472 (2007)
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