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CAS:152612-69-6|N-Acetyl-D-serine

发布时间:2024-06-05 分享至:

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Catalogue Number:A178340
Chemical Name:N-Acetyl-D-serine
Synonyms:(R)-(+)-2-(N-Acetylamino)-3-hydroxypropanoic Acid
CAS Number:152612-69-6
Molecular Formula:C₅H₉NO₄
Appearance:Off-White Solid
Melting Point:86-89°C
Molecular Weight:147.13
Storage:4°C, Inert atmosphere
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Building Blocks; Miscellaneous;
Applications:N-Acetyl-D-serine is the modified amino acid D-Serine (S270975). D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is an potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients.
References:Heresco-Levy, U., et al.: Biol. Psych., 57, 577 (2005); Mothet, J., et al.: Proc. Nat. Acad. Sci., 97, 4926 (2000); Snyder, S. & Kim, P.: Neurochem. Res., 25, 553 (2000); Tsai, G., et al.: Biol. Psych., 44, 1081 (1998)
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