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Catalogue Number:A180180
Chemical Name:1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone
Synonyms:Apixaban Impurity;
CAS Number:1801881-15-1
Molecular Formula:C₁₁H₁₁ClN₂O
Molecular Weight:222.67
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone is an impurity of Apixaban (A726700(P)), which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. Apixaban is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References:Luettgen, J. M., et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T., et al.: J. Thromb. Thrombol., 31, 310 (2011); Barrett, Y. C., et al.: Thromb. Haemos., 105, 181 (2011);
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