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Catalogue Number:A187135
Chemical Name:5-[2-(Acetyloxy)ethyl]-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-2(3H)-thiazolethione
Synonyms:[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-4-thiazoline-2-thione Acetate; 2-(3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-4-methyl-2-thioxo-2,3-dihydrothiazol-5-yl)ethyl acetate
CAS Number:92325-11-6
Molecular Formula:C₁₄H₁₈N₄O₂S₂
Appearance:White Solid
Molecular Weight:338.45
Storage:-20°C
Solubility:Dichloromethane, DMSO, Methanol
Category:Standards; Enzyme Activators and Inhibitors; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-[2-(Acetyloxy)ethyl]-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-2(3H)-thiazolethione is an intermediate in synthesizing Thiothiamine (T375250), an impurity of Thiamine (T344185). Thiothiamine inhibits the activity of glutamate decarboxylase and decreases the concentration of GABA in brain tissue. Thiamine Impurity A.
References:Koval'chuk, V.G. et al.: Tezisy Dokl.- Konf. Beloruss. Biokhim. O-va., 2, 135 (1974); Ostrovskii, Y. et al.: Biokhimiya, 34, 488 (1969)
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