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Catalogue Number:A187570
Chemical Name:2-Acetyl Phenothiazine
Synonyms:ML 171; 1-(10H-Phenothiazin-2-yl)ethanone; Methyl Phenothiazin-2-yl Ketone; 2-Acetyl-10H-phenothiazine; 2-Acetylphenothiazine; NSC 169669; NSC 57951;
CAS Number:6631-94-3
Molecular Formula:C₁₄H₁₁NOS
Appearance:Yellow to Dark Orange Solid
Melting Point:191-193°C
Molecular Weight:241.31
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
References:Gianni, D. et al.: ACS Chem. Biol., 5, 981 (2010); Azuine, M.A. et al.: Pharmacol. Res., 49, 161 (2004);
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