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Catalogue Number:A187698
Chemical Name:7β-Acetyloxy-7α-[9-(dimethyl(tert-butylsilyloxy)nonyl]estr-4-en-3-one
Synonyms:(7α,17β)-17-(Acetyloxy)-7-[9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]nonyl]estr-4-en-3-one
CAS Number:875573-60-7
Molecular Formula:C₃₅H₆₀O₄Si
Molecular Weight:572.93
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Steroids;
Applications:7β-Acetyloxy-7α-[9-(dimethyl(tert-butylsilyloxy)nonyl]estr-4-en-3-one is a useful intermediate in the preparation Fulvestrant (F862502), a steroidal estrogen antagonist.
References:Wakeling, A.E., et al.: Cancer Res., 51, 3867 (1991); Howell, A., et al.: Br. J. Cancer, 74, 300 (1996); Robertson, J.F., et al.: Cancer Res., 61, 6739 (2001); Jiang, Lixun., et al.:Faming Zhuanli Shenqing, CN 103788164 A 20140514. (2014);
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