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Catalogue Number:A188020
Chemical Name:2-[(4-Acetylphenyl)methyl]cyclopentan-1-one
CAS Number:96824-28-1
Molecular Formula:C₁₄H₁₆O₂
Molecular Weight:216.28
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-[(4-Acetylphenyl)methyl]cyclopentan-1-one is a possible metabolite of Loxoprofen (L472900, Na salt), a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
References:Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001)
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