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Catalogue Number:A188765
Chemical Name:(R)-a-[(Acetylthio)methyl]benzenepropanoic Acid
Synonyms:(αR)-α-[(Acetylthio)methyl]benzenepropanoic Acid
CAS Number:116111-79-6
Molecular Formula:C₁₂H₁₄O₃S
Appearance:Colourless Viscous Oil
Molecular Weight:238.3
Solubility:Chloroform, DCM, Ethyl Acetate, Methanol
Category:Building Blocks; Amino Acids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-a-[(Acetylthio)methyl]benzenepropanoic Acid is an intermediate in the synthesis of Retorphan (R278500), a powerful and selective inhibitors of neprilysin and are being developed as therapeutic agents. Retorphan behave as the prodrug of the enantiomers of Thiorphan (T369500).
References:Monteil, T., et al.: Synth. Commun., 31, 211 (2001);
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