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Catalogue Number:A189765
Chemical Name:N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
Synonyms:Ac-YVAD-AFC; N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine
CAS Number:219137-85-6
Molecular Formula:C₃₃H₃₆F₃N₅O₁₀
Appearance:Off-White to Pale Beige Solid
Melting Point:>190°C (dec.)
Molecular Weight:719.66
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Silghtly)
Category:Standards; Fluorescent Reagents;
Applications:N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.
References:Talanian, R. et al.: J. Biol. Chem., 272, 9677 (1977); Marcelli, M. et al.: Cancer Res., 58, 76 (1998);
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