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Catalogue Number:A189875
Chemical Name:Aconitine
Synonyms:(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-Acetate 14-Benzoate;
CAS Number:302-27-2
Molecular Formula:C₃₄H₄₇NO₁₁
Appearance:White to Off-White Solid
Melting Point:>180ºC (dec.)
Molecular Weight:645.74
Storage:4°C
Solubility:Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated), Methanol
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.Used in producing heart arrhythmia in experimental animals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References:Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),
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