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Catalogue Number:A190070
Chemical Name:4-​Amino-​5-​chloro-​N-​[1-​(3-​methoxypropyl)​-​4-​piperidinyl]​-7-​benzofurancarboxamid​e
CAS Number:1900715-96-9
Molecular Formula:C₁₈H₂₄ClN₃O₃
Molecular Weight:365.85
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-​Amino-​5-​chloro-​N-​[1-​(3-​methoxypropyl)​-​4-​piperidinyl]​-7-​benzofurancarboxamid​e is an impurity of Prucalopride Succinate (P838950(P)), which is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. In a more recent analytical study, 4-​Amino-​5-​chloro-​N-​[1-​(3-​methoxypropyl)​-​4-​piperidinyl]​-7-​benzofurancarboxamid​e was selectively separated and characterized as a process impurity of Prucalopride Succinate (P838950(P)) under stress conditions.
References:Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009); Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); Mahamuni, B. S., et al.: J. Pharm. Biomed., 125, 219 (2016);
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