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Catalogue Number:A190245
Chemical Name:Aconine
Synonyms:11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine; Aconitane-3,8,13,14,15-pentol deriv.; Jesaconine
CAS Number:509-20-6
Molecular Formula:C₂₅H₄₁NO₉
Appearance:Off-White to Pale Yellow Solid
Melting Point:>124°C (dec.)
Molecular Weight:499.59
Storage:-20°C
Solubility:Chloroform (Slightly), DMSO (Slightly)
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
References:Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),
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