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Catalogue Number:A217325
Chemical Name:Adarotene
Synonyms:(2E)​-3-​(4'-​Hydroxy-​3'-​tricyclo[3.3.1.13,​7]​dec-​1-​yl[1,​1'-​biphenyl]​-​4-​yl)​-​2-​propenoic Acid; (E)-3-(3'-((3r,5r,7r)-Adamantan-1-yl)-4'-hydroxy-[1,1'-biphenyl]-4-yl)acrylic Acid; ST 1926
CAS Number:496868-77-0
Molecular Formula:C₂₅H₂₆O₃
Molecular Weight:374.47
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Adarotene has been found to have antitumor activity against different types of cancer, including acute myeloid leukemia, primary effusion lymphoma, prostate cancer and glioma. It may also be useful in treating acute lung injury through inflammation and ROS suppression via inactivating TLR4​/NF-​κB and p38​/ERK1​/2 signaling pathways.
References:El-Houjeiri, L., et al.: Mol. Cancer Ther., 16, 2047 (2017); Karam, L., et al.: Oncol. Rep., 39, 721 (2018); Bahmad, H. F., et al.: Mol. Carcinog., 58, 1208 (2019); De, L., et al.: Biomed. Pharmacother., 128, 110291 (2020); Dong, Z., et al.: Int. J. Mol. Med., 41, 3405 (2018)
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