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Catalogue Number:A225100
Chemical Name:Adaptaquin
Synonyms:7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
CAS Number:385786-48-1
Molecular Formula:C₂₁H₁₆ClN₃O₂
Molecular Weight:377.82
Category:Research Tools; Standards; Molecular Biology; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:General Uses:Ischemic injury Research, Renal anemia, HIF Prolyl Hydroxylase Inhibitor, Antioxidant, NeuroprotectiveDescription:Adaptaquin inhibits the HIF PHDs in brain in a dose dependent fashion and penetrates blood brain barrier (BBB). Exhibited functional recovery in intra-cerebral hemorrhage rat model; inhibits ATF4 gene. Potent HIF PHD inhibitor (hypoxia inducible factor), Selective PDH2 inhibitor.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
References:1. Yang Y, et al. 2016. Transl Stroke Res. ; 7(6): 535–547.
2. Vaithinathan S, et al. 2016; Antioxid Redox Signal. 2014 Jun 1; 20(16): 2631–2665.
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