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Catalogue Number:A247530
Chemical Name:Adefovir Dipivoxil Dimer
Synonyms:Adefovir Dipivoxil Impurity B; 2,2-Dimethyl-propanoic Acid Methylenebis[imino-9H-purine-6,9-diyl-2,1-ethanediyloxymethylenephosphinylidynebis(oxymethylene)] Ester
CAS Number:323201-05-4
Molecular Formula:C₄₁H₆₄N₁₀O₁₆P₂
Appearance:Clear Colorless Sticky Gel
Melting Point:No data available
Molecular Weight:1014.95
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Adefovir Dipivoxil Dimer is a formed from the dimerization of Adefovir Dipivoxil (A280465) which is used as an oral reverse transcriptase inhibitor in the treatment of hepatitis B. Adefovir Dipivoxil Dimer’s presence indicates the degradation of Adefovir Dipivoxil under specific conditions suggesting the stability of Adefovir Dipivoxil is compromised under such conditions.
References:Yuan, L., et al.: Pharm. Res., 17, 1098 (2000); Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010)
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