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Catalogue Number:A254845
Chemical Name:Axitinib N-Oxide Tetrahydropyranyl Ether
Synonyms:(E)-2-(2-(6-((2-(Methylcarbamoyl)phenyl)thio)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)vinyl)pyridine 1-Oxide;N-​methyl-​2-​[[3-​[(1E)​-​2-​(1-​oxido-​2-​pyridinyl)​ethenyl]​-​1-​(tetrahydro-​2H-​pyran-​2-​yl)​-​1H-​indazol-​6-​yl]​thio]​-benzamide
CAS Number:2120337-09-7
Molecular Formula:C₂₇H₂₆N₄O₃S
Molecular Weight:486.59
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Axitinib N-Oxide Tetrahydropyranyl Ether is an intermediate in the synthesis of Axitinib N-Oxide (A254850), a metabolite of Axitinib (A794650) which is is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
References:Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),
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