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Catalogue Number:A291670
Chemical Name:AdipoRon
Synonyms:2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide; 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
CAS Number:924416-43-3
Molecular Formula:C₂₇H₂₈N₂O₃
Appearance:White to Off-Whhite Solid
Melting Point:106-108°C
Molecular Weight:428.52
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AdipoRon is an AdipoR agonist and activates AMPK and PPAR-a pathways in the muscle and liver. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
References:Okada-Iwabu, M., et. al.: Nature, 503, 493 (2013)
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