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Catalogue Number:A565183
Chemical Name:7-Amino-6-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-thieno[3,2-b]pyridin-5(4H)-one
Synonyms:7-Amino-6-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)thieno[3,2-b]pyridin-5(4H)-one;7-Amino-6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4H-thieno[3,2-b]pyridin-5-one
CAS Number:2056122-65-5
Molecular Formula:C₁₉H₂₀N₆OS
Molecular Weight:380.47
Category:Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:7-Amino-6-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-thieno[3,2-b]pyridin-5(4H)-one is a HPK1 kinase inhibitor and has been shown to have in vivo antitumor activity. HPK1 kinase has been identified as a novel drug target for antitumor immunotherapy, as this kinase is involved in the extracellular-signaling pathways that inhibit the T-cell immuno antitumor response.
References:Johnson, E., et. al.: J. Biol. Chem., 294, 9029 (2019);Sawasdikosol, S., et. al.: Immunol. Res., 54, 262 (2012);Sampson, P., et. al.: PCT Int. Appl. 93pp Patent 2016 CODEN:PIXXD2
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