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Catalogue Number:A575450
Chemical Name:Aloisine A RP107
Synonyms:RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;
CAS Number:496864-16-5
Molecular Formula:C₁₆H₁₇N₃O
Appearance:Light Orangish Yellow solid
Melting Point:151-153°C (dec.)
Molecular Weight:267.33
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).
References:Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),
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