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Catalogue Number:A575871
Chemical Name:Ambrisentan Methyl Ester
Synonyms:(+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic Acid Methyl Ester; (S)-Methyl 2-((4,6-Dimethylpyrimidin-2-yl)-oxy)-3-methoxy-3,3-diphenylpropanoate;
CAS Number:1106685-61-3
Molecular Formula:C₂₃H₂₄N₂O₄
Appearance:White to Off-White Solid
Melting Point:134 - 136°C
Molecular Weight:392.45
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly, Sonicated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(S)-Methyl 2-((4,6-dimethylpyrimidin-2-yl)-oxy)-3-methoxy-3,3-diphenylpropanoate is a useful intermediate in the preparation of Ambrisentan. Ambrisentan is an Antihypertensive. Ambrisentan Impurity (A575860).
References:Peng, X., et al.: J. Org. Chem., 77, 701 (2012), Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003)
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