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Catalogue Number:A575873
Chemical Name:(R)-Ambrisentan
Synonyms:ent-Ambrisertan; (αR)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic Acid; (R)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid
CAS Number:1007358-76-0
Molecular Formula:C₂₂H₂₂N₂O₄
Appearance:White to Off-White Solid
Melting Point:>161°C (dec.)
Molecular Weight:378.42
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated)
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-Ambrisentan is the R-isomer impurity of Ambrisentan (A575860), which is a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References:Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996); Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002); Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003);
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