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Catalogue Number:A576350
Chemical Name:AMD 3465
Synonyms:N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine Hydrobromide; AMD 3465; GENZ 644494
CAS Number:185991-07-5
Molecular Formula:C₂₄H₄₄Br₆N₆
Appearance:Pale Yellow Solid
Melting Point:>200°C (dec.)
Molecular Weight:896.07
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
Category:Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma
References:Burger, J.A., et al.: Leuke. Lympho.,53. 3 (2012); Lam, A.R., et al.: J. Chem. Info. Model., 51, 139 (2011); De Clercq. E., et al.: Pharmacol. Therap., 128. 509 (2010);
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