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Catalogue Number:A576820
Chemical Name:Amifostine Thiol Dihydrochloride (90%)
Synonyms:2-[(3-Aminopropyl)amino]ethanethiol Hydrochloride; WR 1065
CAS Number:14653-77-1
Alternate CAS #
Free Base: 31098-42-7
Molecular Formula:C₅H₁₆Cl₂N₂S
Appearance:White to Off-White Solid
Melting Point:>183°C (dec.)
Molecular Weight:207.16
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Amifostine Thiol is a metabolite of Amifostine (A576810) which provides normal cells with selective protection against the toxic effects of cancer chemotherapy and radiation treatment.
References:Satge, J., et al.: Eur. J. Med. Chem., 24, 48 (1989); Geary, R.S., et al.: Biopharm. Drug Dispos., 12, 261 (1991); Brown, D.Q., et al. Pharmacol. Ther., 39, 159 (1988); Capizzi, R.L., et al.: Cancer, 72, 3495 (1993); Treskes, M., et al.: Cancer Chemother. Pharmacol., 33, 93 (1993)
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