货号：E-2024052288
CAS：312637-48-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C380165
Chemical Name:(3R)-N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
Synonyms:THIQ
CAS Number:312637-48-2
Molecular Formula:C₃₃H₄₁ClN₆O₂
Molecular Weight:589.17
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Melanocortin 4 receptors play important roles in the regulation of energy homeostasis, eating behavior and sexual functions (1). (3R)-N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide is a potent and selective melanocortin 4 receptor agonist (2,3). It inhibits parasympathetic preganglionic neurons in the brainstem and regulates sympathetic and parasympathetic preganglionic neurons.
References:(1) Link, R., et al.: Eur J Pharmacol. 799, 58 (2017)
(2) Sohn, J.W., et al.: Cell. 152, 612 (2013)
(3) Martin, et al.: Eur. J. Pharmacol., 71, 454, (2002)
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