货号：E-2024052323
CAS：210095-58-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:C380375
Chemical Name:2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine L-Tartrate
Synonyms:2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate
CAS Number:210095-58-2
Alternate CAS #
Free Base: 201594-84-5
Molecular Formula:C₂₁H₂₅ClN₂O₇
Appearance:White to Off-White Solid
Melting Point:175-178ºC
Molecular Weight:452.89
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
Stability
Hygroscopic
Category:Building Blocks; Chiral Molecules;
Applications:2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-dihydroxybutanedioate is used as a reagent to prepare optically active 4-[(4-chlorophenyl-2-pyridyl)methoxy]piperidine, a compound that is used as an intermediate in the synthesis of antihistamines and antiallergy agents. (S)-2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is also an intermediate of Bepotastine besylate (B317000), a non-sedating H1-antagonist that has anti-inflammatory activity.
References:Kita, J. Preparation of Optically Active 4-[(4-Chlorophenyl-2-pyridyl)methoxy]piperidine As A Material For Antihistamines and Antiallergy Agents. Jpn. Kokai Tokkyo Koho JP 10182635. Jul 7, 1998; Ohashi, R., et al.: Drug Metab. Disp., 34, 793 (2006)
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